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Tag: CYP2D6 ultrarapid metabolizer

Codeine and CYP2D6 Ultrarapid Metabolizers: What You Need to Know About Overdose Risk

Codeine and CYP2D6 Ultrarapid Metabolizers: What You Need to Know About Overdose Risk

  • Maria Witham
  • 17 December 2025
  • 15

Codeine can be deadly for people with a genetic trait called CYP2D6 ultrarapid metabolism. Even standard doses can cause fatal overdose by turning too quickly into morphine. Learn who's at risk and what safer alternatives exist.

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