Ever tried an antidepressant that left you tired or with no interest in sex? Wellbutrin often avoids those problems. It's the brand name for bupropion, a medicine used for major depressive disorder and for smoking cessation (sold as Zyban for quitting). Unlike SSRIs, Wellbutrin works on dopamine and norepinephrine — that’s why people call it more "energizing."
Available as immediate‑release, SR (twice daily) and XL (once daily), Wellbutrin comes in different strengths so doctors can tailor the dose. It can help lift mood, increase motivation, and reduce nicotine cravings for people trying to quit smoking.
Typical starting doses: SR often begins at 150 mg once daily for a few days, then 150 mg twice daily. XL usually starts at 150 mg once daily and may increase to 300 mg. Your doctor will pick the exact plan. Don’t crush or split extended‑release tablets unless a pharmacist says it’s okay.
Effects usually show up within 2–6 weeks. Some people feel more alert or energetic in the first week, but mood improvements take time. If you miss a dose, skip it and take the next scheduled dose — don’t double up.
Common complaints are dry mouth, trouble sleeping, headache, and mild anxiety. Many people tolerate it well, especially compared to SSRIs when it comes to sexual side effects.
There’s a rare but real risk of seizures. That risk rises with higher doses and if you have certain conditions: past seizures, brain injury, heavy alcohol use or sudden alcohol/benzodiazepine withdrawal, and eating disorders like bulimia. Also avoid combining with MAO inhibitors — wait at least 14 days between an MAOI and bupropion.
Other important interactions: certain antibiotics and antidepressants can increase bupropion levels. Linezolid or IV methylene blue are special cases where interactions can be dangerous; your prescriber should know if you’ll need those.
Take Wellbutrin in the morning to reduce insomnia. If it causes jitteriness, splitting dose or lowering it may help — check with your prescriber. Don’t drink heavily while on bupropion; alcohol can raise seizure risk and worsen mood swings.
Call your doctor or emergency services if you notice a seizure, severe allergic reaction (rash, swelling, trouble breathing), new or worsening suicidal thoughts, or extreme agitation. Also reach out if you become pregnant or are breastfeeding so your provider can review risks and options.
Want to buy meds online? Only use reputable pharmacies that require a prescription. If something feels off — super low prices, no doctor check, or weird shipping — pause and confirm credentials.
Wellbutrin works well for many people, but it needs careful use. Talk openly with your prescriber about your medical history, current meds, and drinking habits so you get the safest, most effective plan.
Curious about Wellbutrin? This article takes a deep dive into what makes it different from other antidepressants, how it works, who it helps, and what side effects to watch for. We break down everything from dosing tips to surprising benefits, using real-life examples and statistics. If you or someone you know wonders about Wellbutrin, you'll find clear, helpful answers here. Discover why so many prefer this medication, and get straightforward advice for everyday coping.