Comparison NSAIDs: Which One Works Best for Pain and Inflammation?

When you reach for an NSAID, a class of nonsteroidal anti-inflammatory drugs used to reduce pain, fever, and inflammation. Also known as non-opioid pain relievers, they’re one of the most common ways people manage everything from headaches to arthritis. But not all NSAIDs are created equal—some work faster, others last longer, and some carry higher risks for your stomach, kidneys, or heart.

Take ibuprofen, a widely available over-the-counter NSAID often used for short-term pain relief versus naproxen, a longer-acting option that’s better for chronic conditions like osteoarthritis. Ibuprofen kicks in quicker but needs to be taken every 4–6 hours. Naproxen lasts 8–12 hours, so fewer pills per day—but it’s harder on your stomach. Then there’s ketorolac, a potent prescription NSAID used for severe acute pain, but only for up to five days because of serious bleeding and kidney risks. And if you’re looking for something gentler on the joints, diacerein, a slower-acting arthritis drug that targets inflammation at the cartilage level might be worth considering, even if it doesn’t give instant relief.

What you choose depends on what you’re treating, how long you need it, and what other meds you’re on. If you’re on blood thinners, some NSAIDs can raise your risk of bleeding. If you have kidney issues, certain ones like ketorolac are off-limits. And if drowsiness is a concern, you’ll want to avoid NSAIDs that interact with other CNS depressants. The posts below break down real-world comparisons: how ketorolac stacks up against other painkillers, why diacerein is an alternative to NSAIDs for arthritis, and how drugs like cetirizine and levocetirizine show how small chemical changes can cut side effects. You’ll also find guides on managing NSAID risks, spotting dangerous interactions, and switching safely when one stops working. No fluff. Just clear, practical comparisons to help you make smarter choices.